Answer 1

You probably mean one of these:

while my_variable == True:
do indented block until my_variable somehow becomes False (or break)

while True:
do indented block forever (there's no variable to set 'False') or until break

Because the question's syntax is problematic ( = is assignment, == is an equivalency test / TRUE should be True / you also need a colon to start the loop block):

>>> while=TRUE
File "<stdin>", line 1
while=TRUE
^
SyntaxError: invalid syntax