How to make game in python

Answer 1

Learn python until your are able to create a game. ;)

Answer 2

Python is not really a language made for games. But you can try, if we are talking clean python (not engines that use python)
You should probably start off by learning how to make a basic tic tac toe with python, and move on. You wont get any graphics, you will have to make the games console-based. Unless you use Tkinter or another interface import to have a window for a game, but that's basically it.
On the other side, there are game engines that support python. Blender Game Engine or Python-Ogre game engine.

If you want to program a proper game from scratch, use Java.