Answer 1

In Python you can try RenPy (2D) or such as:

2D engines for beginners: Stencyl (constructor), RPG-maker, RenPy(whith python). Ink - free whith Unity (html, c#). GameMaker Studio2 (100$, drag&drop), and Only Unity (make 2D too whith packages 2D)

Answer 2

Animation on what platform? PC, mob app, web brousers?

Answer 3

Engines: Unity, Cryengine V (C++), Unreal engine 4 (pc, vr, playstations), PL - C# & C++, C-Sharp, JavaScript (Construct 2), Gamemaker(only 2D, whithout PL)

Answer 4

Unity, unreal engine 4, c#, c++