What are the implications of python gui.

Answer 1

Implications? How do you mean it?
If you want to do desktop GUI, you should look into tkinter - it's the easiest way because it comes with the standard library.
If it's for Android, www.kivy.org is the typical answer.

Answer 2

PyQt is also a great cross platform GUI package.
https://wiki.python.org/moin/PyQt/Tutorials